IN VITRO GENERATION OF NEUROMESODERMAL PROGENITORS REVEALS DISTINCT ROLES FOR WNT SIGNALLING IN THE SPECIFICATION OF SPINAL CORD AND PARAXIAL MESODERM IDENTITY.

Cells of the spinal cord and somites arise from shared, dual-fated precursors, located towards the posterior of the elongating embryo.Here we show that these neuromesodermal progenitors (NMPs) can readily be generated in vitro from mouse and human pluripotent stem cells by activating Wnt and Fgf signalling, timed to emulate in vivo development.Simi

BackgroundClear Cell Renal Cell Carcinoma (ccRCC) is the most common type of kidney cancer, characterized by high heterogeneity and complexity.Recent studies have identified mitochondrial defects and autophagy as key players in the development of ccRCC.This study aims to delve into the changes in mitophagic activity within ccRCC and its impact on t

The construction industry turbosound ts-18sw700/8a has been trying to adapt to the requirements and performance criteria imposed by the publication of the Brazilian Performance Standard - NBR 15.575: 2013.Although compliance with technical standards has a mandatory character protected by the Consumer Protection Code in Brazil, there is not an agent

Abstract Background Honey is a highly nutritional natural product that has been widely used in folk medicine for here a number of therapeutic purposes.We evaluated whether Malaysian Tualang honey (AgroMas, Malaysia) was effective in reducing menopausal syndrome in ovariectomised female rats; an animal model for menopause.Methods The rats were divid